Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy

• Published in: Cell host & microbe Vol. 31; no. 1; pp. 83 - 96.e5
• Main Authors: Lian, Xiaodong, Seiger, Kyra W., Parsons, Elizabeth M., Gao, Ce, Sun, Weiwei, Gladkov, Gregory T., Roseto, Isabelle C., Einkauf, Kevin B., Osborn, Matthew R., Chevalier, Joshua M., Jiang, Chenyang, Blackmer, Jane, Carrington, Mary, Rosenberg, Eric S., Lederman, Michael M., McMahon, Deborah K., Bosch, Ronald J., Jacobson, Jeffrey M., Gandhi, Rajesh T., Peluso, Michael J., Chun, Tae-Wook, Deeks, Steven G., Yu, Xu G., Lichterfeld, Mathias
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.01.2023; Cell Press
• Subjects: Anti-Retroviral Agents - therapeutic use; Antiviral Agents - therapeutic use; block and lock; CD4-Positive T-Lymphocytes; FLIP-seq; Heterochromatin; HIV; HIV cure; HIV eradication; HIV Infections; HIV-1 - genetics; Humans; integration sites; latency; MIP-seq; post-treatment controllers; Proviruses - genetics; retroviral pathogenesis; Viral Load; Virus Latency; HIV; FLIP-seq; post-treatment controllers; latency; block and lock; MIP-seq; integration sites; HIV eradication; retroviral pathogenesis; HIV cure

HIV-1 establishes a life-long reservoir of virally infected cells which cannot be eliminated by antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile of long-term ART-treated individuals, characterized by large clones of intact proviruses preferentially integr...