PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

• Published in: Pharmaceutics Vol. 16; no. 1; p. 96
• Main Authors: Le Merdy, Maxime, Szeto, Ke Xu, Perrier, Jeremy, Bolger, Michael B, Lukacova, Viera
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2024; MDPI
• Subjects: Analysis; Clinical trials; Computer software industry; Drug dosages; Enzymes; Females; Fetuses; Gestational age; in silico; Lamotrigine; Liver; metabolic clearance; Metabolism; Metabolites; Metronidazole; PBPK; Physiological aspects; Physiology; Pregnancy; Pregnant women; Simulation; United States; PBPK; metabolic clearance; in silico; pregnancy

This study aimed to develop a physiologically based pharmacokinetic (PBPK) model that simulates metabolically cleared compounds' pharmacokinetics (PK) in pregnant subjects and fetuses. This model accounts for the differences in tissue sizes, blood flow rates, enzyme expression levels, plasma pr...