White Spot Syndrome Virus Establishes a Novel IE1/JNK/c-Jun Positive Feedback Loop to Drive Replication

• Published in: iScience Vol. 23; no. 1; p. 100752
• Main Authors: Wang, Sheng, Li, Haoyang, Weng, Shaoping, Li, Chaozheng, He, Jianguo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.01.2020; Elsevier
• Subjects: Biological Sciences; Molecular Biology; Molecular Microbiology; Virology; Biological Sciences; Molecular Biology; Virology; Molecular Microbiology

Viruses need to hijack and manipulate host proteins to guarantee their replication. Herein, we uncovered that the DNA virus white spot syndrome virus (WSSV) established a novel positive feedback loop by hijacking the host JNK pathway via its immediate-early 1 (IE1) protein to drive replication. Spec...