Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 45; no. 2; pp. 327 - 336
• Main Authors: Luo, Audrey, Jung, Jeesun, Longley, Martha, Rosoff, Daniel B., Charlet, Katrin, Muench, Christine, Lee, Jisoo, Hodgkinson, Colin A., Goldman, David, Horvath, Steve, Kaminsky, Zachary A., Lohoff, Falk W.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.01.2020; Springer International Publishing
• Subjects: Adult; Age; Aging; Aging - blood; Aging - genetics; Alanine; Alanine transaminase; Alcohol use; Alcoholism - blood; Alcoholism - diagnosis; Alcoholism - genetics; Apolipoproteins; Apolipoproteins L - genetics; Body mass index; Cohort Studies; DNA methylation; DNA Methylation - genetics; Drinking behavior; Epigenesis, Genetic - genetics; Epigenetics; Female; Gene expression; Genetic diversity; Genetic Variation - genetics; Genome-wide association studies; Genome-Wide Association Study - methods; Genomes; Humans; Male; Middle Aged; Phenotypes; Quantitative trait loci; Single-nucleotide polymorphism; Systematic review; γ-Glutamyltransferase

To investigate the potential role of alcohol use disorder (AUD) in aging processes, we employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in 331 individuals with AUD and 201 healthy controls (HC). We evaluated the effects of heavy, chronic alcohol consumption on...