Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

• Published in: eLife Vol. 12
• Main Authors: Ding, Yufang, Yanagi, Karin, Yang, Fang, Callaway, Evelyn, Cheng, Clint, Hensel, Martha E, Menon, Rani, Alaniz, Robert C, Lee, Kyongbum, Jayaraman, Arul
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 27.02.2024; eLife Sciences Publications Ltd
• Subjects: Acetates; Acetic acid; AMP-activated protein kinase; Analysis; Animals; Bile; Cecum; Cytokines; Diet; Diet, Western - adverse effects; Dietary Supplements; Digestive system; Drinking water; Dysbacteriosis; Enzymes; Fatty acids; Fatty liver; Feces; Food; Gastrointestinal Microbiome; Gastrointestinal tract; Hepatocytes; High fat diet; indole-3-acetic acid; Indoles - pharmacology; Inflammation; Intestinal microflora; Intestine; Kinases; Lipogenesis; Liver; Liver diseases; Macrophages; Mann-Whitney U test; Metabolism; Metabolites; Metagenomics; Mice; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Non-alcoholic Fatty Liver Disease - drug therapy; Oral administration; Protein kinases; Proteomes; Scientific equipment and supplies industry; Steatosis; Triglycerides; Tryptophan; United States; Massachusetts; California; microbiota; mouse; inflammation; liver; medicine; immunology; indole-3-acetic acid

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the pathology of NAFLD. We previously demonstrated that gut micr...