Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice - Ding, Yufang; Yanagi, Karin; Yang, Fang; Callaway, Evelyn; Cheng, Clint; Hensel, Martha E; Menon, Rani; Alaniz, Robert C; Lee, Kyongbum; Jayaraman, Arul (eLife, 2024)
Keywords: Acetates; Acetic acid; AMP-activated protein kinase; Analysis; Animals; Bile; Cecum; Cytokines; Diet; Diet, Western - adverse effects; Dietary Supplements; Digestive system; Drinking water; Dysbacteriosis; Enzymes; Fatty acids; Fatty liver; Feces; Food; Gastrointestinal Microbiome; Gastrointestinal tract; Hepatocytes; High fat diet; indole-3-acetic acid; Indoles - pharmacology; Inflammation; Intestinal microflora; Intestine; Kinases; Lipogenesis; Liver; Liver diseases; Macrophages; Mann-Whitney U test; Metabolism; Metabolites; Metagenomics; Mice; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Non-alcoholic Fatty Liver Disease - drug therapy; Oral administration; Protein kinases; Proteomes; Scientific equipment and supplies industry; Steatosis; Triglycerides; Tryptophan; United States; Massachusetts; California; microbiota; mouse; inflammation; liver; medicine; immunology; indole-3-acetic acid