Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

• Published in: Cell metabolism Vol. 31; no. 6; pp. 1136 - 1153.e7
• Main Authors: Zhang, Jing, Muri, Jonathan, Fitzgerald, Gillian, Gorski, Tatiane, Gianni-Barrera, Roberto, Masschelein, Evi, D’Hulst, Gommaar, Gilardoni, Paola, Turiel, Guillermo, Fan, Zheng, Wang, TongTong, Planque, Mélanie, Carmeliet, Peter, Pellerin, Luc, Wolfrum, Christian, Fendt, Sarah-Maria, Banfi, Andrea, Stockmann, Christian, Soro-Arnáiz, Inés, Kopf, Manfred, De Bock, Katrien
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.06.2020; Cell Press
• Subjects: angiogenesis; angriocrine signals; Animals; Cells, Cultured; endothelial cells; Endothelial Cells - chemistry; ischemia; Ischemia - metabolism; Ischemia - pathology; lactate; Lactates - pharmacology; Macrophage Activation - drug effects; macrophage polarization; Macrophages - drug effects; Macrophages - metabolism; MCT1; metabolism; Mice; Mice, Knockout; Mice, Transgenic; muscle regeneration; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; endothelial cells; angiogenesis; MCT1; macrophage polarization; metabolism; muscle regeneration; angriocrine signals; lactate; ischemia

Endothelial cell (EC)-derived signals contribute to organ regeneration, but angiocrine metabolic communication is not described. We found that EC-specific loss of the glycolytic regulator pfkfb3 reduced ischemic hindlimb revascularization and impaired muscle regeneration. This was caused by the redu...