Enantioselective Copper-Catalyzed Cyanation of Remote C(sp3)-H Bonds Enabled by 1,5-Hydrogen Atom Transfer

• Published in: iScience Vol. 21; pp. 490 - 498
• Main Authors: Wang, Cheng-Yu, Qin, Zi-Yang, Huang, Yu-Ling, Jin, Ruo-Xing, Lan, Quan, Wang, Xi-Sheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.11.2019; Elsevier
• Subjects: Catalysis; Organic Synthesis; Stereochemistry; Organic Synthesis; Catalysis; Stereochemistry

The direct functionalization of C(sp3)-H bonds has led to the development of methods to access molecules or intermediates from basic chemicals in an atom- and step-economic fashion. Nevertheless, achieving high levels of chemo-, regio-, and enantioselectivity in these reactions remains challenging d...