Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility

Highlights • Streptococcus pneumoniae serotype 19A is a frequent pathogen in infants aged ≤60 days. • Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) in infants aged ≤60 days. • Theoretical serotype coverage among children ag...

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Published inInternational journal of infectious diseases Vol. 42; no. C; pp. 69 - 73
Main Authors Soto-Noguerón, Araceli, Carnalla-Barajas, María Noemí, Solórzano-Santos, Fortino, Arrendondo-García, José Luis, Arzate-Barbosa, Patricia, Tinoco-Favila, Juan Carlos, Anzurez-Gutiérrez, Azarell, Echániz-Aviles, Gabriela
Format Journal Article
LanguageEnglish
Published Canada Elsevier Ltd 01.01.2016
Elsevier
Subjects
Antimicrobial susceptibility
Female
Humans
Infant
Infant, Newborn
Infectious Disease
Invasive pneumococcal diseases
Male
Microbial Sensitivity Tests
Newborns
Pneumococcal Infections - microbiology
Pneumococcal vaccines
Pulmonary/Respiratory
Retrospective Studies
Serotypes
Serotyping
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - drug effects
Newborns
Serotypes
Pneumococcal vaccines
Antimicrobial susceptibility
Invasive pneumococcal diseases
Streptococcus pneumoniae
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Abstract Highlights • Streptococcus pneumoniae serotype 19A is a frequent pathogen in infants aged ≤60 days. • Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) in infants aged ≤60 days. • Theoretical serotype coverage among children aged ≤60 days during the period 2000–2014 was 63.5% for PCV13.
AbstractList •Streptococcus pneumoniae serotype 19A is a frequent pathogen in infants aged ≤60 days.•Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) in infants aged ≤60 days.•Theoretical serotype coverage among children aged ≤60 days during the period 2000–2014 was 63.5% for PCV13. The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and non-invasive disease in children aged ≤60 days in hospitals in Mexico. A 15-year retrospective study was conducted for the period 2000 to 2014. Pneumococcal clinical isolates were serotyped by Quellung reaction, and antimicrobial susceptibility testing was performed with the broth microdilution method. A total of 126 pneumococcal isolates were collected. Pneumonia was the most frequent diagnosis (40.5%), followed by meningitis (29.4%), septicemia (16.7%), and other clinical entities, including otitis media and conjunctivitis (13.5%). The most frequent serotypes before the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) were 19F, 23F, 7F, and 35B. Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of PCV7. Serotype 19A was isolated most frequently in the pneumonia and meningitis cases only after the introduction of PCV7, and it displayed a high resistance to penicillin. Although the number of infections in infants aged ≤60 days was low, such infections were not unusual events. New vaccination strategies should be evaluated to limit the risks in this age group.
Highlights • Streptococcus pneumoniae serotype 19A is a frequent pathogen in infants aged ≤60 days. • Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) in infants aged ≤60 days. • Theoretical serotype coverage among children aged ≤60 days during the period 2000–2014 was 63.5% for PCV13.
Objective: The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and non-invasive disease in children aged ≤60 days in hospitals in Mexico. Methods: A 15-year retrospective study was conducted for the period 2000 to 2014. Pneumococcal clinical isolates were serotyped by Quellung reaction, and antimicrobial susceptibility testing was performed with the broth microdilution method. Results: A total of 126 pneumococcal isolates were collected. Pneumonia was the most frequent diagnosis (40.5%), followed by meningitis (29.4%), septicemia (16.7%), and other clinical entities, including otitis media and conjunctivitis (13.5%). The most frequent serotypes before the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) were 19F, 23F, 7F, and 35B. Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of PCV7. Serotype 19A was isolated most frequently in the pneumonia and meningitis cases only after the introduction of PCV7, and it displayed a high resistance to penicillin. Conclusions: Although the number of infections in infants aged ≤60 days was low, such infections were not unusual events. New vaccination strategies should be evaluated to limit the risks in this age group.
The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and non-invasive disease in children aged ≤60 days in hospitals in Mexico. A 15-year retrospective study was conducted for the period 2000 to 2014. Pneumococcal clinical isolates were serotyped by Quellung reaction, and antimicrobial susceptibility testing was performed with the broth microdilution method. A total of 126 pneumococcal isolates were collected. Pneumonia was the most frequent diagnosis (40.5%), followed by meningitis (29.4%), septicemia (16.7%), and other clinical entities, including otitis media and conjunctivitis (13.5%). The most frequent serotypes before the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) were 19F, 23F, 7F, and 35B. Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of PCV7. Serotype 19A was isolated most frequently in the pneumonia and meningitis cases only after the introduction of PCV7, and it displayed a high resistance to penicillin. Although the number of infections in infants aged ≤60 days was low, such infections were not unusual events. New vaccination strategies should be evaluated to limit the risks in this age group.
OBJECTIVEThe aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and non-invasive disease in children aged ≤60 days in hospitals in Mexico.METHODSA 15-year retrospective study was conducted for the period 2000 to 2014. Pneumococcal clinical isolates were serotyped by Quellung reaction, and antimicrobial susceptibility testing was performed with the broth microdilution method.RESULTSA total of 126 pneumococcal isolates were collected. Pneumonia was the most frequent diagnosis (40.5%), followed by meningitis (29.4%), septicemia (16.7%), and other clinical entities, including otitis media and conjunctivitis (13.5%). The most frequent serotypes before the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) were 19F, 23F, 7F, and 35B. Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of PCV7. Serotype 19A was isolated most frequently in the pneumonia and meningitis cases only after the introduction of PCV7, and it displayed a high resistance to penicillin.CONCLUSIONSAlthough the number of infections in infants aged ≤60 days was low, such infections were not unusual events. New vaccination strategies should be evaluated to limit the risks in this age group.
Author Solórzano-Santos, Fortino
Arrendondo-García, José Luis
Echániz-Aviles, Gabriela
Soto-Noguerón, Araceli
Carnalla-Barajas, María Noemí
Arzate-Barbosa, Patricia
Tinoco-Favila, Juan Carlos
Anzurez-Gutiérrez, Azarell
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  fullname: Echániz-Aviles, Gabriela
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Issue C
Keywords Newborns
Serotypes
Pneumococcal vaccines
Antimicrobial susceptibility
Invasive pneumococcal diseases
Streptococcus pneumoniae
Language English
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Snippet Highlights • Streptococcus pneumoniae serotype 19A is a frequent pathogen in infants aged ≤60 days. • Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the...
•Streptococcus pneumoniae serotype 19A is a frequent pathogen in infants aged ≤60 days.•Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction...
The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates...
OBJECTIVEThe aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical...
Objective: The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical...
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SubjectTerms Antimicrobial susceptibility
Female
Humans
Infant
Infant, Newborn
Infectious Disease
Invasive pneumococcal diseases
Male
Microbial Sensitivity Tests
Newborns
Pneumococcal Infections - microbiology
Pneumococcal vaccines
Pulmonary/Respiratory
Retrospective Studies
Serotypes
Serotyping
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - drug effects
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Title Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility
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Volume 42
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