A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

• Published in: iScience Vol. 25; no. 8; p. 104787
• Main Authors: Jackson, Thomas R., Vuorinen, Aini, Josa-Culleré, Laia, Madden, Katrina S., Conole, Daniel, Cogswell, Thomas J., Wilkinson, Isabel V.L., Kettyle, Laura M., Zhang, Douzi, O’Mahony, Alison, Gracias, Deanne, McCall, Lorna, Westwood, Robert, Terstappen, Georg C., Davies, Stephen G., Tate, Edward W., Wynne, Graham M., Vyas, Paresh, Russell, Angela J., Milne, Thomas A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.08.2022; Elsevier
• Subjects: Biological sciences; Cancer; Chemistry; Molecular biology; Molecular medicine; Chemistry; Biological sciences; Molecular biology; Molecular medicine; Cancer

Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple AML subtypes. One common factor across AML subtypes is the...