Lipid mediators of inflammation in rheumatoid arthritis and osteoarthritis

• Published in: Best practice & research. Clinical rheumatology Vol. 29; no. 6; pp. 741 - 755
• Main Authors: Brouwers, Hilde, von Hegedus, Joost, Toes, René, Kloppenburg, Margreet, Ioan-Facsinay, Andreea
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2015
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - pathology; Humans; Inflammation; Inflammation - drug therapy; Inflammation - pathology; Inflammation Mediators - metabolism; Lipid mediators; Lipids; Lipids - chemistry; Mice; Osteoarthritis; Osteoarthritis - pathology; Oxylipins; Rheumatoid arthritis; Rheumatology; Synovial Fluid - chemistry; Lipids; Inflammation; Lipid mediators; Osteoarthritis; Rheumatoid arthritis; Oxylipins

Abstract Rheumatoid arthritis (RA) and osteoarthritis (OA) are inflammatory joint diseases, characterized by pain and structural damage. Besides prostaglandins, usually targeted by non-steroidal anti-inflammatory drugs, other lipids, including fatty acids, phospholipids and other bioactive lipid med...