Mycophenolate mofetil : fully utilizing its benefits for GvHD prophylaxis

• Published in: International journal of hematology Vol. 96; no. 1; pp. 10 - 25
• Main Authors: Minagawa, Kentaro, Yamamori, Motohiro, Katayama, Yoshio, Matsui, Toshimitsu
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.07.2012; Springer; Springer Nature B.V
• Subjects: Biological and medical sciences; Biomarkers - metabolism; Cord Blood Stem Cell Transplantation - adverse effects; Graft Survival - drug effects; Graft vs Host Disease - drug therapy; Graft vs Host Disease - prevention & control; Graft-versus-host disease (GvHD); Hematologic and hematopoietic diseases; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Histocompatibility; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - pharmacokinetics; Immunosuppressive Agents - therapeutic use; Medical sciences; Medicine; Medicine & Public Health; Methotrexate - therapeutic use; Mycophenolate acid (MPA); Mycophenolate mofetil (MMF); Mycophenolic Acid - administration & dosage; Mycophenolic Acid - adverse effects; Mycophenolic Acid - analogs & derivatives; Mycophenolic Acid - metabolism; Mycophenolic Acid - pharmacokinetics; Mycophenolic Acid - therapeutic use; Oncology; Prognosis; Review Article; Therapeutic drug monitoring (TDM); Tissue Donors; Mycophenolate mofetil (MMF); Graft-versus-host disease (GvHD); Therapeutic drug monitoring (TDM); Mycophenolate acid (MPA); Immunopathology; Graft versus host disease; Mycophenolic acid; Hematology; Enzyme; Stem cell; IMP dehydrogenase; Enzyme inhibitor; Hematopoietic cell; Homograft; Prevention; Therapeutic drug monitoring; Graft; Oxidoreductases; Immunosuppressive agent; Mycophenolate mofetil; Inosine monophosphate dehydrogenase inhibitor

Mycophenolate mofetil (MMF) has been widely used for the prophylaxis of graft-versus-host disease (GvHD) in hematopoietic stem cell transplantation (HSCT), based on clinical evidence established in organ transplantations. MMF is not a cytotoxic, but rather a cytostatic agent, and there have been sev...