Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study
Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1–16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant...
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| Published in | Saudi pharmaceutical journal Vol. 27; no. 1; pp. 133 - 137 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Saudi Arabia
Elsevier B.V
01.01.2019
Elsevier |
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| Abstract | Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1–16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent.
Density functional theory was carried out to explain the relative importance of CO, CS and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents. |
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| AbstractList | Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1–16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent.Density functional theory was carried out to explain the relative importance of CO, CS and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents. Keywords: Benzotriazoloquinazolines, DPPH, BHT, DFT, Antioxidant capacity Previously, a series of 2-phenoxy-benzo[ ]triazoloquinazolines were synthesized and fully characterized. The antioxidant activity of the target molecules - was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds and have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent. Density functional theory was carried out to explain the relative importance of C[bond, double bond]O, C[bond, double bond]S and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents. Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1–16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent. Density functional theory was carried out to explain the relative importance of CO, CS and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents. Previously, a series of 2-phenoxy-benzo[ g ]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target molecules 1 – 16 was evaluated using three different assays namely 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some benzotriazoloquinazolines showed good activity and have the capacity to scavenge free radicals. In particular, compounds 1 and 14 have shown the highest activity. The butylated hydroxyl toluene (BHT) used as standard agent. Density functional theory was carried out to explain the relative importance of C Created by potrace 1.16, written by Peter Selinger 2001-2019 O, C S and NH groups on the radical scavenging activity of the target benzotriazoloquinazolines. The finding in present study shows that the active compounds can be used as template for further development of more potent antioxidant agents. |
| Author | Al-Salahi, Rashad ElHassane, Anouar Taie, Hanan A.A. Marzouk, Mohamed Almehizia, Abdulrahman A. Abuelizz, Hatem A. |
| Author_xml | – sequence: 1 givenname: Abdulrahman A. orcidid: 0000-0001-8711-3873 surname: Almehizia fullname: Almehizia, Abdulrahman A. organization: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia – sequence: 2 givenname: Hatem A. surname: Abuelizz fullname: Abuelizz, Hatem A. organization: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia – sequence: 3 givenname: Hanan A.A. surname: Taie fullname: Taie, Hanan A.A. organization: Plant Biochemistry Department, Division of Agriculture & Biological Researches, National Research Centre, 33 El-Bohouth St.(Former El-Tahrir St.), Dokki, 12622 Giza, Egypt – sequence: 4 givenname: Anouar surname: ElHassane fullname: ElHassane, Anouar organization: Department of Chemistry, College of Science and Humanities, Prince Sattam bin Abdulaziz University, P.O. Box 83, Alkharj 11942, Saudi Arabia – sequence: 5 givenname: Mohamed surname: Marzouk fullname: Marzouk, Mohamed organization: Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences, National Research Centre, 33 El-Bohouth St.(Former El-Tahrir St.), Dokki 12622, Giza, Egypt – sequence: 6 givenname: Rashad orcidid: 0000-0003-1747-2736 surname: Al-Salahi fullname: Al-Salahi, Rashad email: ralsalahi@ksu.edu.sa organization: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia |
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| Keywords | Antioxidant capacity DFT Benzotriazoloquinazolines DPPH BHT |
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| Snippet | Previously, a series of 2-phenoxy-benzo[g]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target molecules... Previously, a series of 2-phenoxy-benzo[ ]triazoloquinazolines were synthesized and fully characterized. The antioxidant activity of the target molecules - was... Previously, a series of 2-phenoxy-benzo[ g ]triazoloquinazolines 1–16 were synthesized and fully characterized. The antioxidant activity of the target... |
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| SubjectTerms | Antioxidant capacity Benzotriazoloquinazolines BHT DFT DPPH Original |
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| Title | Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study |
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