Quercetin alleviates acute kidney injury by inhibiting ferroptosis

• Published in: Journal of advanced research Vol. 28; pp. 231 - 243
• Main Authors: Wang, Yue, Quan, Fei, Cao, Qiuhua, Lin, Yanting, Yue, Chongxiu, Bi, Ran, Cui, Xinmeng, Yang, Hongbao, Yang, Yong, Birnbaumer, Lutz, Li, Xianjing, Gao, Xinghua
• Format: Journal Article
• Language: English
• Published: Egypt Elsevier B.V 01.02.2021; Elsevier
• Subjects: Activation transcription factor 3; Acute kidney injury; Ferroptosis; Macrophages; Quercetin; Activation transcription factor 3; Ferroptosis; Macrophages; Acute kidney injury; Quercetin

A proposed model illustrating the therapeutic effect of QCT on AKI. QCT inhibits the expression of ATF3. While ATF3 blocks the system Xc-, and then suppresses GPX4, inducing ferroptosis. In another side, ferroptotic cells secrete chemokines like CCL2, CCL7, induce the recruitment of macrophages, and...