Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

• Published in: Cell metabolism Vol. 26; no. 4; pp. 672 - 685.e4
• Main Authors: Li, Guolin, Xie, Cen, Lu, Siyu, Nichols, Robert G., Tian, Yuan, Li, Licen, Patel, Daxeshkumar, Ma, Yinyan, Brocker, Chad N., Yan, Tingting, Krausz, Kristopher W., Xiang, Rong, Gavrilova, Oksana, Patterson, Andrew D., Gonzalez, Frank J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.10.2017
• Subjects: Adipose Tissue, Beige - metabolism; Adipose Tissue, White - metabolism; Animals; beige adipocytes; browning; Energy Metabolism; every-other-day fasting (EODF); Fasting; Fatty Liver - complications; Fatty Liver - metabolism; Fatty Liver - microbiology; Fatty Liver - therapy; Fibroblast Growth Factors - metabolism; Gastrointestinal Microbiome; gut microbiota; Insulin Resistance; intermittent fasting; metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - metabolism; Metabolic Syndrome - microbiology; Metabolic Syndrome - therapy; Mice, Inbred C57BL; obesity; Obesity - complications; Obesity - metabolism; Obesity - microbiology; Obesity - therapy; short-chain fatty acid; Signal Transduction; Thermogenesis; metabolic syndrome; short-chain fatty acid; intermittent fasting; every-other-day fasting (EODF); browning; beige adipocytes; gut microbiota; obesity

While activation of beige thermogenesis is a promising approach for treatment of obesity-associated diseases, there are currently no known pharmacological means of inducing beiging in humans. Intermittent fasting is an effective and natural strategy for weight control, but the mechanism for its effi...