The Gut Virome Database Reveals Age-Dependent Patterns of Virome Diversity in the Human Gut

• Published in: Cell host & microbe Vol. 28; no. 5; pp. 724 - 740.e8
• Main Authors: Gregory, Ann C., Zablocki, Olivier, Zayed, Ahmed A., Howell, Allison, Bolduc, Benjamin, Sullivan, Matthew B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.11.2020
• Subjects: bacteriophage; Bacteriophages; Databases, Factual; dysbiosis; Dysbiosis - virology; Feces - virology; Gastrointestinal Tract - virology; Genome, Viral; gut microbiome; human health; Humans; lifespan; Longevity; Metagenome; Resource; Virion; Virome; virus; Virus Diseases - virology; virome; database; gut microbiome; lifespan; bacteriophage; virus; human health; dysbiosis

The gut microbiome profoundly affects human health and disease, and their infecting viruses are likely as important, but often missed because of reference database limitations. Here, we (1) built a human Gut Virome Database (GVD) from 2,697 viral particle or microbial metagenomes from 1,986 individu...