Analysis of Trans-Ancestral SLE Risk Loci Identifies Unique Biologic Networks and Drug Targets in African and European Ancestries

• Published in: American journal of human genetics Vol. 107; no. 5; pp. 864 - 881
• Main Authors: Owen, Katherine A., Price, Andrew, Ainsworth, Hannah, Aidukaitis, Bryce N., Bachali, Prathyusha, Catalina, Michelle D., Dittman, James M., Howard, Timothy D., Kingsmore, Kathryn M., Labonte, Adam C., Marion, Miranda C., Robl, Robert D., Zimmerman, Kip D., Langefeld, Carl D., Grammer, Amrie C., Lipsky, Peter E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.11.2020; Elsevier
• Subjects: ancesty; B-Lymphocytes - immunology; B-Lymphocytes - pathology; Black People; Bortezomib - therapeutic use; DNA, Intergenic - genetics; DNA, Intergenic - immunology; drug repurposing; Enhancer Elements, Genetic; Gene Expression; Gene Ontology; Gene Regulatory Networks; Genetic Predisposition to Disease; genetics; Genome, Human; Genome-Wide Association Study; GWAS; Heterocyclic Compounds - therapeutic use; Humans; Immunochip; Interferons - genetics; Interferons - immunology; Isoquinolines - therapeutic use; Lactams; lupus; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - ethnology; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Molecular Sequence Annotation; pathway analysis; Polymorphism, Single Nucleotide; Protein Array Analysis; Quantitative Trait Loci; Quantitative Trait, Heritable; SLE; White People; drug repurposing; genetics; GWAS; Immunochip; pathway analysis; SLE; ancesty; lupus

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Individuals of African ancestry (AA) experience the disease more severely and with an increased co-morbidity burden compared to European ancestry (EA) populations. We hypothesize that the disp...