Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial

• Published in: European journal of pharmaceutical sciences Vol. 157; p. 105631
• Main Authors: Lou, Yan, Liu, Lin, Yao, Hangping, Hu, Xingjiang, Su, Junwei, Xu, Kaijin, Luo, Rui, Yang, Xi, He, Lingjuan, Lu, Xiaoyang, Zhao, Qingwei, Liang, Tingbo, Qiu, Yunqing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2021
• Subjects: Amides - administration & dosage; Amides - blood; Amides - pharmacokinetics; Antiviral Agents - administration & dosage; Antiviral Agents - blood; Antiviral Agents - pharmacokinetics; baloxavir marboxil; COVID-19; COVID-19 - blood; COVID-19 - diagnosis; COVID-19 - drug therapy; COVID-19 - physiopathology; Dibenzothiepins - administration & dosage; Dibenzothiepins - blood; Dibenzothiepins - pharmacokinetics; Drug Monitoring - methods; favipiravir; Female; Humans; Inhibitory Concentration 50; Male; Middle Aged; Morpholines - administration & dosage; Morpholines - blood; Morpholines - pharmacokinetics; pharmacokinetics; Pyrazines - administration & dosage; Pyrazines - blood; Pyrazines - pharmacokinetics; Pyridones - administration & dosage; Pyridones - blood; Pyridones - pharmacokinetics; SARS-CoV-2 - drug effects; SARS-CoV-2 - isolation & purification; SARS-CoV-2 - physiology; Symptom Assessment; the half-maximal effective concentration (EC50); Treatment Outcome; Triazines - administration & dosage; Triazines - blood; Triazines - pharmacokinetics; Viral Load - drug effects; ECMO; CRP; PCT; AST; SARS-CoV; ALT; the half-maximal effective concentration (EC50); Cmin; COVID-19; LDH; baloxavir marboxil; RT-PCR; pharmacokinetics; EC50; WBC; ICU; favipiravir; COPD; CPK; the half-maximal effective concentration (EC)
• ISSN: 0928-0987; 1879-0720; 1879-0720
• DOI: 10.1016/j.ejps.2020.105631

•An exploratory randomized, controlled trial of baloxavir marboxil and favipiravir in COVID-19 patients were conducted.•The free drug concentrations of baloxavir acid and favipiravir are generally lower than their respective EC50 values.•Add-on either baloxavir or favipiravir to the current standard...