Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs

• Published in: Acta pharmaceutica Sinica. B Vol. 12; no. 6; pp. 2624 - 2639
• Main Authors: Li, Yamin, Ye, Zhongfeng, Yang, Hanyi, Xu, Qiaobing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2022; Elsevier
• Subjects: Cancer therapy; Combinatorial library; Drug delivery; Gene therapy; Lipid nanoparticle; Protein delivery; Review; Protein delivery; Drug delivery; Gene therapy; Cancer therapy; Lipid nanoparticle; Combinatorial library

Lipid nanoparticle (LNP)-based drug delivery systems have become the most clinically advanced non-viral delivery technology. LNPs can encapsulate and deliver a wide variety of bioactive agents, including the small molecule drugs, proteins and peptides, and nucleic acids. However, as the physicochemi...