Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program

• Published in: iScience Vol. 15; pp. 79 - 94
• Main Authors: Sánchez-de-Diego, Cristina, Artigas, Natalia, Pimenta-Lopes, Carolina, Valer, José Antonio, Torrejon, Benjamin, Gama-Pérez, Pau, Villena, Josep A., Garcia-Roves, Pablo M., Rosa, José Luis, Ventura, Francesc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.05.2019; Elsevier
• Subjects: Molecular Mechanism of Behavior; Molecular Physiology; Specialized Functions of Cells; Molecular Physiology; Molecular Mechanism of Behavior; Specialized Functions of Cells

Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients and likely affects their differentiation, a process that remains poorly defined. Here, we show that restriction in glucose supply promotes the...