Modulation of Cyp450, ALS1 and COX-2 signaling pathways induced by Candida albicans infection via novel antifungal agents

• Published in: Saudi pharmaceutical journal Vol. 26; no. 3; pp. 349 - 357
• Main Authors: Abdel Megeed, Rehab M, Fayed, Dalia B., Abood, Amira, Kadry, Mai O
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01.03.2018; Elsevier
• Subjects: ALS1; Candida albicans; COX-2; Cyp450; Fluconazole; Candida albicans; Fluconazole; Cyp450; COX-2; ALS1

Although, fluconazole is widely used in clinical treatment as an antifungal drug, it recorded potential problems as resistance and intracellular accumulation. Female albino mice were injected with single ip dose of Candida albicans (1.5 × 106 CFU). Three weeks post treatment with fluconazole and two...