Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy

• Published in: International journal of pharmaceutics: X Vol. 5; p. 100148
• Main Authors: Trenfield, Sarah J., Xu, Xiaoyan, Goyanes, Alvaro, Rowland, Martin, Wilsdon, David, Gaisford, Simon, Basit, Abdul W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2023; Elsevier
• Subjects: 3D printed medicines; Additive manufacturing; Powder bed fusion printing; Printed drug delivery systems and pharmaceuticals; Process analytical technology tools; Special Issue on Latest trends in pharmaceutical printing; Process analytical technology tools; Printed drug delivery systems and pharmaceuticals; Additive manufacturing; Powder bed fusion printing; 3D printed medicines

Selective laser sintering (SLS) 3D printing is a revolutionary 3D printing technology that has been found capable of creating drug products with varied release profiles by changing the laser scanning speed. Here, SLS 3D printed formulations (printlets) loaded with a narrow therapeutic index drug (th...