High-Throughput Preparation of Antibacterial Polymers from Natural Product Derivatives via the Hantzsch Reaction

The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihyd...

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Published iniScience Vol. 23; no. 1; p. 100754
Main Authors Liu, Guoqiang, Zhang, Qiang, Li, Yongsan, Wang, Xing, Wu, Haibo, Wei, Yen, Zeng, Yuan, Tao, Lei
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 24.01.2020
Elsevier
Subjects
Natural Product Chemistry
Organic Chemistry
Polymers
Polymers
Natural Product Chemistry
Organic Chemistry
Online AccessGet full text
ISSN2589-0042
2589-0042
DOI10.1016/j.isci.2019.100754

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Abstract The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods led to the identification of an antibacterial polymer. Mechanistic studies revealed that the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering functional polymers for possible practical applications. It also provides insights to further developing new functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science. [Display omitted] •A one-pot high-throughput (HTP) system was developed to prepare a polymer library•A new antibacterial polymer was selected from this library via HTP measurements•This antibacterial polymer was mixed in polyethylene to get antibacterial utensils•Mechanism study revealed that the Hantzsch reaction leads to new antibacterial polymers Organic Chemistry; Natural Product Chemistry; Polymers
AbstractList The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods led to the identification of an antibacterial polymer. Mechanistic studies revealed that the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering functional polymers for possible practical applications. It also provides insights to further developing new functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science. [Display omitted] •A one-pot high-throughput (HTP) system was developed to prepare a polymer library•A new antibacterial polymer was selected from this library via HTP measurements•This antibacterial polymer was mixed in polyethylene to get antibacterial utensils•Mechanism study revealed that the Hantzsch reaction leads to new antibacterial polymers Organic Chemistry; Natural Product Chemistry; Polymers
The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods led to the identification of an antibacterial polymer. Mechanistic studies revealed that the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering functional polymers for possible practical applications. It also provides insights to further developing new functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science.The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods led to the identification of an antibacterial polymer. Mechanistic studies revealed that the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering functional polymers for possible practical applications. It also provides insights to further developing new functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science.
The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods led to the identification of an antibacterial polymer. Mechanistic studies revealed that the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering functional polymers for possible practical applications. It also provides insights to further developing new functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science. • A one-pot high-throughput (HTP) system was developed to prepare a polymer library • A new antibacterial polymer was selected from this library via HTP measurements • This antibacterial polymer was mixed in polyethylene to get antibacterial utensils • Mechanism study revealed that the Hantzsch reaction leads to new antibacterial polymers Organic Chemistry; Natural Product Chemistry; Polymers
The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods led to the identification of an antibacterial polymer. Mechanistic studies revealed that the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering functional polymers for possible practical applications. It also provides insights to further developing new functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science. : Organic Chemistry; Natural Product Chemistry; Polymers Subject Areas: Organic Chemistry, Natural Product Chemistry, Polymers
The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in parallel. Six aldehydes derived from natural products were used as the starting materials to rapidly prepare the library of 30 poly(1,4-dihydropyridines). From this library, HTP evaluation methods led to the identification of an antibacterial polymer. Mechanistic studies revealed that the dihydropyridine group in the polymer side-chain structure plays an important role in resisting bacterial attachment to the polymer surface, thus leading to the antibacterial function of this polymer. This research demonstrates the value of multicomponent reactions (MCRs) in interdisciplinary fields by discovering functional polymers for possible practical applications. It also provides insights to further developing new functional polymers using MCRs and HTP methods with important implications in organic chemistry, polymer chemistry, and materials science.
ArticleNumber 100754
Author Li, Yongsan
Zeng, Yuan
Zhang, Qiang
Wu, Haibo
Wei, Yen
Liu, Guoqiang
Wang, Xing
Tao, Lei
AuthorAffiliation 3 Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China
2 Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China
1 The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
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Keywords Polymers
Natural Product Chemistry
Organic Chemistry
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Snippet The Hantzsch and free-radical polymerization reactions were combined in a one-pot high-throughput (HTP) system to simultaneously prepare 30 unique polymers in...
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SubjectTerms Natural Product Chemistry
Organic Chemistry
Polymers
Title High-Throughput Preparation of Antibacterial Polymers from Natural Product Derivatives via the Hantzsch Reaction
URI https://dx.doi.org/10.1016/j.isci.2019.100754
https://www.ncbi.nlm.nih.gov/pubmed/31884171
https://www.proquest.com/docview/2331430648
https://pubmed.ncbi.nlm.nih.gov/PMC6941863
https://doaj.org/article/c74a16ab4d244c8887f5e6f7ae64ee80
Volume 23
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