Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling

• Published in: Cell Vol. 159; no. 1; pp. 122 - 133
• Main Authors: Peng, Min, Yin, Na, Li, Ming O.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.09.2014
• Subjects: Amino Acid Sequence; Amino Acids - metabolism; AMP-Activated Protein Kinases - metabolism; Animals; Animals, Newborn; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Embryo, Mammalian - cytology; Female; Fibroblasts - metabolism; Gene Knock-In Techniques; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Molecular Sequence Data; Monomeric GTP-Binding Proteins - genetics; Monomeric GTP-Binding Proteins - metabolism; Multiprotein Complexes - metabolism; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Pregnancy; Sequence Alignment; Signal Transduction; Starvation - metabolism; TOR Serine-Threonine Kinases - metabolism; Tumor Suppressor Proteins - metabolism

Mechanistic target of rapamycin complex 1 (mTORC1) integrates diverse environmental signals to control cellular growth and organismal homeostasis. In response to nutrients, Rag GTPases recruit mTORC1 to the lysosome to be activated, but how Rags are regulated remains incompletely understood. Here, w...