Recent advances in the neuropsychopharmacology of serotonergic hallucinogens

• Published in: Behavioural brain research Vol. 277; pp. 99 - 120
• Main Author: Halberstadt, Adam L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2015
• Subjects: 5-HT2A receptor; Animals; Behavior, Animal - drug effects; Brain - drug effects; Brain - metabolism; Exploratory Behavior - drug effects; Exploratory Behavior - physiology; Hallucinogens - pharmacology; Head twitch; Humans; Lysergic Acid Diethylamide - pharmacology; Prefrontal cortex; Psychedelic; Receptor, Serotonin, 5-HT2A - drug effects; Receptor, Serotonin, 5-HT2A - metabolism; Visual effects; Visual effects; 5-HT2A receptor; Prefrontal cortex; Head twitch; Psychedelic

•Serotonergic hallucinogens are classified as phenylalkylamines and indoleamines.•The two classes of hallucinogens produce similar subjective effects in humans and show cross-tolerance.•Hallucinogen effects are primarily mediated by the serotonin 5-HT2A receptor.•Many effects of hallucinogens are me...