Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury

• Published in: Kidney international Vol. 84; no. 3; pp. 509 - 520
• Main Authors: Zhou, Dong, Tan, Roderick J., Lin, Lin, Zhou, Lili, Liu, Youhua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2013; Elsevier Limited
• Subjects: acute kidney injury; Acute Kidney Injury - etiology; Acute Kidney Injury - physiopathology; Acute Kidney Injury - prevention & control; Animals; apoptosis; Apoptosis - physiology; bcl-2-Associated X Protein - metabolism; c-met; Cisplatin - adverse effects; Creatinine - blood; Disease Models, Animal; Fas Ligand Protein - metabolism; HGF; inflammation; Kidney Tubules - physiology; Mice; Mice, Knockout; Mice, Transgenic; Proto-Oncogene Proteins c-met - deficiency; Proto-Oncogene Proteins c-met - genetics; Proto-Oncogene Proteins c-met - physiology; Reperfusion Injury - complications; Signal Transduction - physiology; apoptosis; acute kidney injury; c-met; inflammation; HGF

Hepatocyte growth factor is a pleiotrophic protein that promotes injury repair and regeneration in multiple organs. Here, we show that after acute kidney injury (AKI), the HGF receptor, c-met, was induced predominantly in renal tubular epithelium. To investigate the role of tubule-specific induction...