Toward Rational Understandings of α-C–H Functionalization: Energetic Studies of Representative Tertiary Amines

• Published in: iScience Vol. 23; no. 2; p. 100851
• Main Authors: Luo, Wenzhi, Yang, Jin-Dong, Cheng, Jin-Pei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.02.2020; Elsevier
• Subjects: Organic Chemistry; Organic Synthesis; Physical Organic Chemistry; Physical Organic Chemistry; Organic Synthesis; Organic Chemistry

Functionalization of α-C–H bonds of tertiary amines to build various α-C–X bonds has become a mainstream in synthetic chemistry nowadays. However, due to lack of fundamental knowledge on α-C–H bond strength as an energetic guideline, rational exploration of new synthetic methodologies remains a far-...