Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 143; no. 4; pp. 913 - 916.e7
• Main Authors: Vrieze, Anne, Van Nood, Els, Holleman, Frits, Salojärvi, Jarkko, Kootte, Ruud S., Bartelsman, Joep F.W.M., Dallinga–Thie, Geesje M., Ackermans, Mariette T., Serlie, Mireille J., Oozeer, Raish, Derrien, Muriel, Druesne, Anne, Van Hylckama Vlieg, Johan E.T., Bloks, Vincent W., Groen, Albert K., Heilig, Hans G.H.J., Zoetendal, Erwin G., Stroes, Erik S., de Vos, Willem M., Hoekstra, Joost B.L., Nieuwdorp, Max
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2012
• Subjects: Adult; Alcaligenes faecalis; Bacteria; Bacteroidetes; Blood Glucose - metabolism; Body Mass Index; butyrate; Clinical Trial; Clostridium; Diabetes; Escherichia coli; Eubacterium; Fatty Acids, Volatile - metabolism; Feces - chemistry; Feces - microbiology; Gastroenterology and Hepatology; gut microbiome; Humans; Insulin Resistance; Intestine, Small - microbiology; Male; Metabolic Syndrome - blood; Metabolic Syndrome - therapy; Metagenome; Middle Aged; obesity; Oxalobacter formigenes; probe; resistance; Short-Chain Fatty Acids; Statistics, Nonparametric; storage; tract; Rd; REE; Clinical Trial; Short-Chain Fatty Acids; Bacteria; Diabetes; BMI; EGP; resting energy expenditure; endogenous glucose production; body mass index; rate of disposal

Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned...