Structural insights into emergent signaling modes of G protein–coupled receptors

• Published in: The Journal of biological chemistry Vol. 295; no. 33; pp. 11626 - 11642
• Main Authors: Sutkeviciute, Ieva, Vilardaga, Jean-Pierre
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.08.2020; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; arrestin; beta-Arrestins - metabolism; cAMP; cyclic AMP (cAMP); Cyclic AMP - metabolism; endosomal membrane; endosome; Endosomes - metabolism; Endosomes - pathology; environmental sensing; G protein-coupled receptor (GPCR); Humans; JBC Reviews; membrane lipid; Membrane Lipids - metabolism; Models, Molecular; parathyroid hormone; Protein Conformation; receptor structure-function; Receptors, G-Protein-Coupled - chemistry; Receptors, G-Protein-Coupled - metabolism; Signal Transduction; structural dynamics; structure-function; β-arrestins; parathyroid hormone; signal transduction; membrane lipid; structure-function; β-arrestins; cyclic AMP (cAMP); cAMP; arrestin; receptor structure-function; environmental sensing; endosome; endosomal membrane; structural dynamics; G protein-coupled receptor (GPCR)

G protein–coupled receptors (GPCRs) represent the largest family of cell membrane proteins, with >800 GPCRs in humans alone, and recognize highly diverse ligands, ranging from photons to large protein molecules. Very important to human medicine, GPCRs are targeted by about 35% of prescription dru...