A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

• Published in: Science (American Association for the Advancement of Science) Vol. 369; no. 6507
• Main Authors: Suzuki, Kunimichi, Elegheert, Jonathan, Song, Inseon, Sasakura, Hiroyuki, Senkov, Oleg, Matsuda, Keiko, Kakegawa, Wataru, Clayton, Amber J, Chang, Veronica T, Ferrer-Ferrer, Maura, Miura, Eriko, Kaushik, Rahul, Ikeno, Masashi, Morioka, Yuki, Takeuchi, Yuka, Shimada, Tatsuya, Otsuka, Shintaro, Stoyanov, Stoyan, Watanabe, Masahiko, Takeuchi, Kosei, Dityatev, Alexander, Aricescu, A Radu, Yuzaki, Michisuke
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 28.08.2020; American Association for the Advancement of Science (AAAS)
• Subjects: Affinity; Alzheimer Disease - therapy; Alzheimer's disease; Anatomy; Animal diseases; Animal models; Animals; Ataxia; Autism; Autism Spectrum Disorders; Balance; Binding; Biochemistry, Molecular Biology; Brain; C-Reactive Protein - chemistry; C-Reactive Protein - pharmacology; C-Reactive Protein - therapeutic use; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Cell differentiation; Cell surface; Cerebellar ataxia; Cerebellar Ataxia - therapy; Cerebellum; Circuit design; Circuits; Differentiation; Disease Models, Animal; Domains; Epilepsy; Gait; Granule cells; HEK293 Cells; Hippocampus; Humans; Individualized Instruction; Information retrieval; Injuries; Life Sciences; Locomotion; Long-term potentiation; Mental disorders; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins - chemistry; Nerve Tissue Proteins - pharmacology; Nerve Tissue Proteins - therapeutic use; Nervous system; Neural networks; Neural Pathways - drug effects; Neurodegenerative diseases; Neurological disorders; Neurons; Neurotransmitters; Physiology; Protein Domains; Protein Precursors - chemistry; Protein Precursors - pharmacology; Protein Precursors - therapeutic use; Proteins; Receptors, AMPA - metabolism; Receptors, Glutamate - genetics; Recombinant Proteins - chemistry; Recombinant Proteins - pharmacology; Recombinant Proteins - therapeutic use; Recovery of function; Schizophrenia; Spinal cord; Spinal cord injuries; Spine; Spine - drug effects; Spine - physiology; Structural Elements (Construction); Structural members; Synapses; Synapses - drug effects; Synaptogenesis; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors

Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also perturb the excitatory-inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders. Molecular tools to rest...