Synthesis of Self-Assembled Nanostructured Cisplatin Using the RESS Process

• Published in: Pharmaceutics Vol. 16; no. 11; p. 1471
• Main Authors: Sharma, Sudhir Kumar, Palanikumar, Loganathan, Pasricha, Renu, Prakasam, Thirumurugan, Magzoub, Mazin, Jagannathan, Ramesh
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2024; MDPI
• Subjects: apoptosis; Cancer; Cancer therapies; Carbon dioxide; Care and treatment; Cell research; cell viability; Cisplatin; Cytotoxicity; Drug delivery systems; Ethylenediaminetetraacetic acid; Leukemia; liquid in situ transmission electron microscopy; Raman spectroscopy; RESS technique; Side effects; supercritical CO2 processing; United States; United Arab Emirates; liquid in situ transmission electron microscopy; supercritical CO2 processing; apoptosis; RESS technique; cell viability

Background/Objectives: The primary goal of our research is to develop a process to prepare an aqueous dispersion of Cisplatin, an important anticancer drug, with increased solubility and storage stability. Method: In this context, we report the use of a customized RESS process for the synthesis of a...