Detection of genomic mutations in katG and rpoB genes among multidrug-resistant Mycobacterium tuberculosis isolates from Tehran, Iran

• Published in: New microbes and new infections Vol. 41; p. 100879
• Main Authors: Motavaf, B., Keshavarz, N., Ghorbanian, F., Firuzabadi, S., Hosseini, F., Zaker Bostanabad, S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2021; Elsevier
• Subjects: Isoniazid; katG; multidrug-resistant; Mycobacterium tuberculosis; Original; rifampin; rpoB; katG; Mycobacterium tuberculosis; rpoB; Isoniazid; rifampin; multidrug-resistant

Multidrug-resistant (MDR) Mycobacterium tuberculosis strains, defined as resistant to at least isoniazid and rifampin, have emerged as a major worldwide health threat. Spontaneous point mutations in various genes of M. tuberculosis cause resistance to isoniazid, with the most frequent gene target be...