Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

• Published in: Cell host & microbe Vol. 16; no. 6; pp. 795 - 805
• Main Authors: Watanabe, Tokiko, Kawakami, Eiryo, Shoemaker, Jason E., Lopes, Tiago J.S., Matsuoka, Yukiko, Tomita, Yuriko, Kozuka-Hata, Hiroko, Gorai, Takeo, Kuwahara, Tomoko, Takeda, Eiji, Nagata, Atsushi, Takano, Ryo, Kiso, Maki, Yamashita, Makoto, Sakai-Tagawa, Yuko, Katsura, Hiroaki, Nonaka, Naoki, Fujii, Hiroko, Fujii, Ken, Sugita, Yukihiko, Noda, Takeshi, Goto, Hideo, Fukuyama, Satoshi, Watanabe, Shinji, Neumann, Gabriele, Oyama, Masaaki, Kitano, Hiroaki, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.12.2014
• Subjects: Antiviral Agents - pharmacology; Drug Evaluation, Preclinical; Guanine Nucleotide Exchange Factors - antagonists & inhibitors; Guanine Nucleotide Exchange Factors - genetics; Guanine Nucleotide Exchange Factors - metabolism; Host-Pathogen Interactions - drug effects; Humans; Influenza, Human - drug therapy; Influenza, Human - genetics; Influenza, Human - metabolism; Influenza, Human - virology; Janus Kinase 1 - antagonists & inhibitors; Janus Kinase 1 - genetics; Janus Kinase 1 - metabolism; Orthomyxoviridae - drug effects; Orthomyxoviridae - genetics; Orthomyxoviridae - metabolism; Protein Binding - drug effects; Protein Interaction Mapping - methods; Protein Interaction Maps - drug effects; Viral Proteins - genetics; Viral Proteins - metabolism

Host factors required for viral replication are ideal drug targets because they are less likely than viral proteins to mutate under drug-mediated selective pressure. Although genome-wide screens have identified host proteins involved in influenza virus replication, limited mechanistic understanding...