In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration

• Published in: Cell stem cell Vol. 26; no. 1; pp. 34 - 47.e3
• Main Authors: Matsumoto, Tomonori, Wakefield, Leslie, Tarlow, Branden David, Grompe, Markus
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.01.2020
• Subjects: Cell Proliferation; hepatocyte; Hepatocytes; Humans; lineage tracing; Liver; Liver Regeneration; ploidy conveyor; ploidy reduction; Polyploidy; ploidy conveyor; ploidy reduction; hepatocyte; lineage tracing; polyploidy

The identity of cellular populations that drive liver regeneration after injury is the subject of intense study, and the contributions of polyploid hepatocytes to organ regeneration and homeostasis have not been systematically assessed. Here, we developed a multicolor reporter allele system to genet...