Durability of immune responses to the BNT162b2 mRNA vaccine

Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination. Substantial waning of antibody responses to the Pfizer-BioNTech mRNA vaccine 6 months after the second vaccination.

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Published in	Med (New York, N.Y. : Online) Vol. 3; no. 1; pp. 25 - 27
Main Authors	Suthar, Mehul S., Arunachalam, Prabhu S., Hu, Mengyun, Reis, Noah, Trisal, Meera, Raeber, Olivia, Chinthrajah, Sharon, Davis-Gardner, Meredith E., Manning, Kelly, Mudvari, Prakriti, Boritz, Eli, Godbole, Sucheta, Henry, Amy R., Douek, Daniel C., Halfmann, Peter, Kawaoka, Yoshihiro, Boyd, Scott D., Davis, Mark M., Zarnitsyna, Veronika I., Nadeau, Kari, Pulendran, Bali
Format	Journal Article
Language	English
Published	United States Elsevier Inc 14.01.2022
Subjects	Antibody Formation BNT162 Vaccine COVID-19 - prevention & control COVID-19 Vaccines Humans mRNA Vaccines Vaccines, Synthetic
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Abstract	Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination. Substantial waning of antibody responses to the Pfizer-BioNTech mRNA vaccine 6 months after the second vaccination.
AbstractList	Substantial waning of antibody responses to the Pfizer-BioNTech mRNA vaccine 6 months after the second vaccination. Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination.Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination. Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination. Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination. Substantial waning of antibody responses to the Pfizer-BioNTech mRNA vaccine 6 months after the second vaccination.
Author	Douek, Daniel C. Davis-Gardner, Meredith E. Godbole, Sucheta Hu, Mengyun Suthar, Mehul S. Boritz, Eli Henry, Amy R. Arunachalam, Prabhu S. Chinthrajah, Sharon Pulendran, Bali Manning, Kelly Reis, Noah Zarnitsyna, Veronika I. Kawaoka, Yoshihiro Boyd, Scott D. Nadeau, Kari Mudvari, Prakriti Raeber, Olivia Trisal, Meera Halfmann, Peter Davis, Mark M.
AuthorAffiliation	7 University of Tokyo, Tokyo, Japan 4 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 9 Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA 3 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA 10 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA 2 Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA 6 National Center for Global Health and Medicine, Tokyo, Japan 8 Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA 5 University of Wisconsin, Madison, WI, USA 1 Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA 11 Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA
AuthorAffiliation_xml	– name: 10 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA – name: 11 Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA – name: 4 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA – name: 7 University of Tokyo, Tokyo, Japan – name: 9 Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA – name: 5 University of Wisconsin, Madison, WI, USA – name: 8 Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA – name: 6 National Center for Global Health and Medicine, Tokyo, Japan – name: 3 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA – name: 1 Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA – name: 2 Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA
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Cites_doi	10.1002/cpim.116 10.1056/NEJMoa2114228 10.1056/NEJMoa2114583 10.1126/science.abj4176 10.1038/s41586-021-03791-x 10.1016/j.cell.2021.03.036 10.1016/j.xcrm.2021.100354 10.1056/NEJMc2103916 10.1371/journal.pbio.2006601
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Snippet	Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination. Substantial waning of antibody responses to... Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination. Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination.Antibody responses to the Pfizer-BioNTech mRNA... Substantial waning of antibody responses to the Pfizer-BioNTech mRNA vaccine 6 months after the second vaccination.
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SubjectTerms	Antibody Formation BNT162 Vaccine COVID-19 - prevention & control COVID-19 Vaccines Humans mRNA Vaccines Vaccines, Synthetic
Title	Durability of immune responses to the BNT162b2 mRNA vaccine
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