The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo

• Published in: Clinical and translational radiation oncology Vol. 2; no. C; pp. 7 - 12
• Main Authors: Liebscher, Steffi, Koi, Lydia, Löck, Steffen, Muders, Michael H., Krause, Mechthild
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.02.2017; Elsevier
• Subjects: Growth delay; Irradiation; Local tumor control; Nelfinavir; Prostate cancer; Radiosensitization; Irradiation; Growth delay; Radiosensitization; Local tumor control; Prostate cancer; Nelfinavir

Radiotherapy has a high curative potential in localized prostate cancer, however, there are still patients with locally advanced tumours who face a considerable risk of recurrence. Radiosensitization using molecular targeted drugs could help to optimize treatment for this high-risk group. The PI3K/A...