Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins

• Published in: Cell stem cell Vol. 21; no. 3; pp. 349 - 358.e6
• Main Authors: Yoon, Ki-Jun, Song, Guang, Qian, Xuyu, Pan, Jianbo, Xu, Dan, Rho, Hee-Sool, Kim, Nam-Shik, Habela, Christa, Zheng, Lily, Jacob, Fadi, Zhang, Feiran, Lee, Emily M., Huang, Wei-Kai, Ringeling, Francisca Rojas, Vissers, Caroline, Li, Cui, Yuan, Ling, Kang, Koeun, Kim, Sunghan, Yeo, Junghoon, Cheng, Yichen, Liu, Sheng, Wen, Zhexing, Qin, Cheng-Feng, Wu, Qingfeng, Christian, Kimberly M., Tang, Hengli, Jin, Peng, Xu, Zhiheng, Qian, Jiang, Zhu, Heng, Song, Hongjun, Ming, Guo-li
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.09.2017
• Subjects: adherens junction; Adherens Junctions - metabolism; Animals; Cell Differentiation; Cell Proliferation; Cerebral Cortex - embryology; Cerebral Cortex - metabolism; cortical neurogenesis; flavivirus; HEK293 Cells; human organoid; human protein microarray; Humans; Mammals - metabolism; Membrane Proteins - metabolism; Mice; microcephaly; neural stem cell; Neurogenesis; Neuroglia - pathology; neuronal migration; Protein Binding; Protein Interaction Mapping; Proteolysis; radial glial cell; Viral Nonstructural Proteins - metabolism; Zika virus; Zika Virus - metabolism; Zika Virus Infection - pathology; microcephaly; radial glial cell; neural stem cell; adherens junction; cortical neurogenesis; neuronal migration; human organoid; human protein microarray; Zika virus; flavivirus

Zika virus (ZIKV) directly infects neural progenitors and impairs their proliferation. How ZIKV interacts with the host molecular machinery to impact neurogenesis in vivo is not well understood. Here, by systematically introducing individual proteins encoded by ZIKV into the embryonic mouse cortex,...