Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability

• Published in: iScience Vol. 13; pp. 488 - 497
• Main Authors: Kategaya, Lorn, Perumal, Senthil K., Hager, Jeffrey H., Belmont, Lisa D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.03.2019; Elsevier
• Subjects: Biological Sciences; Cancer; Molecular Biology; Molecular Biology; Biological Sciences; Cancer

Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions between WRN and another human RecQ helicase, BLM, with DNA d...