Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells

• Published in: Molecular therapy. Methods & clinical development Vol. 28; pp. 1 - 10
• Main Authors: Corey, Daniel, Haeseleer, Francoise, Hou, Joe, Corey, Lawrence
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.03.2023; American Society of Gene & Cell Therapy; Elsevier
• Subjects: chimeric engulfment receptor (CER); HIV; Original; phosphatidylserine; SIV; TIM-4; SIV; phosphatidylserine; HIV; chimeric engulfment receptor (CER); TIM-4

Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV)-infected cells express phosphatidylserine (PS) early post infection. We tested whether chimeric engulfment receptor (CER) T cel...