Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

• Published in: Cell metabolism Vol. 31; no. 2; pp. 284 - 300.e7
• Main Authors: Bensard, Claire L., Wisidagama, Dona R., Olson, Kristofor A., Berg, Jordan A., Krah, Nathan M., Schell, John C., Nowinski, Sara M., Fogarty, Sarah, Bott, Alex J., Wei, Peng, Dove, Katja K., Tanner, Jason M., Panic, Vanja, Cluntun, Ahmad, Lettlova, Sandra, Earl, Christian S., Namnath, David F., Vázquez-Arreguín, Karina, Villanueva, Claudio J., Tantin, Dean, Murtaugh, L. Charles, Evason, Kimberley J., Ducker, Gregory S., Thummel, Carl S., Rutter, Jared
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.02.2020
• Subjects: Adenoma - metabolism; Animals; cancer metabolism; carbohydrate metabolism; Carcinogenesis - metabolism; Cell Transformation, Neoplastic - metabolism; colon cancer; Colorectal Neoplasms - metabolism; Drosophila; Female; Male; Mice; Mice, Inbred C57BL; mitochondria; Mitochondria - metabolism; Mitochondrial Membrane Transport Proteins - metabolism; pyruvate metabolism; Pyruvic Acid - metabolism; stem cell metabolism; tumor initiation; cancer metabolism; stem cell metabolism; carbohydrate metabolism; colon cancer; mitochondria; pyruvate metabolism; tumor initiation

Although metabolic adaptations have been demonstrated to be essential for tumor cell proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including...