Multiple Origins of Virus Persistence during Natural Control of HIV Infection

• Published in: Cell Vol. 166; no. 4; pp. 1004 - 1015
• Main Authors: Boritz, Eli A., Darko, Samuel, Swaszek, Luke, Wolf, Gideon, Wells, David, Wu, Xiaolin, Henry, Amy R., Laboune, Farida, Hu, Jianfei, Ambrozak, David, Hughes, Marybeth S., Hoh, Rebecca, Casazza, Joseph P., Vostal, Alexander, Bunis, Daniel, Nganou-Makamdop, Krystelle, Lee, James S., Migueles, Stephen A., Koup, Richard A., Connors, Mark, Moir, Susan, Schacker, Timothy, Maldarelli, Frank, Hughes, Stephen H., Deeks, Steven G., Douek, Daniel C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.08.2016
• Subjects: Blood - virology; CD4-Positive T-Lymphocytes - immunology; Chronic Disease; DNA, Viral - genetics; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - physiology; Humans; Leukocytes, Mononuclear; Lymph Nodes - virology; Proviruses - immunology; Sequence Analysis, DNA; Virus Physiological Phenomena; Virus Replication

Targeted HIV cure strategies require definition of the mechanisms that maintain the virus. Here, we tracked HIV replication and the persistence of infected CD4 T cells in individuals with natural virologic control by sequencing viruses, T cell receptor genes, HIV integration sites, and cellular tran...