Benefits of Metformin in Attenuating the Hallmarks of Aging
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial—...
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| Published in | Cell metabolism Vol. 32; no. 1; pp. 15 - 30 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
07.07.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial—TAME (targeting aging by metformin). This review focuses on metformin’s mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials.
Metformin is the first drug to be tested for its age-targeting effects in a large clinical trial. In this perspective, Kulkarni et al. review how metformin acts on its primary and secondary targets to attenuate the hallmarks of aging, highlighting its utility as an effective gerotherapeutic intervention. |
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| AbstractList | Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin- a biguanide that combats age-related disorders and improves healthspan, is the first drug to be tested for its age-targeting effects in the large clinical trial- TAME (Targeting Aging by MEtformin). This review focuses on metformin’s mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient-sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem-cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials.
Metformin is the first drug to be tested for its age-targeting effects in a large clinical trial. In this Perspective, Kulkarni et al. review how metformin acts on its primary and secondary targets to attenuate the hallmarks of aging, highlighting its utility as an effective gerotherapeutic intervention. Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial-TAME (targeting aging by metformin). This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials. Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial-TAME (targeting aging by metformin). This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials.Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial-TAME (targeting aging by metformin). This review focuses on metformin's mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials. Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested for its age-targeting effects in the large clinical trial—TAME (targeting aging by metformin). This review focuses on metformin’s mechanisms in attenuating hallmarks of aging and their interconnectivity, by improving nutrient sensing, enhancing autophagy and intercellular communication, protecting against macromolecular damage, delaying stem cell aging, modulating mitochondrial function, regulating transcription, and lowering telomere attrition and senescence. These characteristics make metformin an attractive gerotherapeutic to translate to human trials. Metformin is the first drug to be tested for its age-targeting effects in a large clinical trial. In this perspective, Kulkarni et al. review how metformin acts on its primary and secondary targets to attenuate the hallmarks of aging, highlighting its utility as an effective gerotherapeutic intervention. |
| Author | Kulkarni, Ameya S. Gubbi, Sriram Barzilai, Nir |
| AuthorAffiliation | 3 Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 1 Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York 2 Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York |
| AuthorAffiliation_xml | – name: 2 Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York – name: 1 Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York – name: 3 Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland |
| Author_xml | – sequence: 1 givenname: Ameya S. surname: Kulkarni fullname: Kulkarni, Ameya S. email: ameyak225@gmail.com organization: Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, NY, USA – sequence: 2 givenname: Sriram surname: Gubbi fullname: Gubbi, Sriram organization: Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA – sequence: 3 givenname: Nir surname: Barzilai fullname: Barzilai, Nir email: nir.barzilai@einsteinmed.org organization: Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, NY, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32333835$$D View this record in MEDLINE/PubMed |
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| Snippet | Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that... Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin- a biguanide that... |
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| SubjectTerms | aging Aging - drug effects Aging - metabolism aging hallmarks Animals Autophagy - drug effects Cell Communication - drug effects Cellular Senescence - drug effects health span Humans Hypoglycemic Agents - pharmacology longevity metabolism metformin Metformin - pharmacology Mitochondria - drug effects Mitochondria - metabolism TAME |
| Title | Benefits of Metformin in Attenuating the Hallmarks of Aging |
| URI | https://dx.doi.org/10.1016/j.cmet.2020.04.001 https://www.ncbi.nlm.nih.gov/pubmed/32333835 https://www.proquest.com/docview/2394882211 https://pubmed.ncbi.nlm.nih.gov/PMC7347426 |
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