Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing

Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but the importance and regulation of these changes remain unclear. We found that hepcidin, the master regulator of systemic iron homeostasis, is required for tissue repair in the mouse intestine after experimental da...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 368; no. 6487; pp. 186 - 189
Main Authors Bessman, Nicholas J, Mathieu, Jacques R R, Renassia, Cyril, Zhou, Lei, Fung, Thomas C, Fernandez, Keith C, Austin, Christine, Moeller, Jesper B, Zumerle, Sara, Louis, Sabine, Vaulont, Sophie, Ajami, Nadim J, Sokol, Harry, Putzel, Gregory G, Arvedson, Tara, Sockolow, Robbyn E, Lakhal-Littleton, Samira, Cloonan, Suzanne M, Arora, Manish, Peyssonnaux, Carole, Sonnenberg, Gregory F
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 10.04.2020
American Association for the Advancement of Science (AAAS)
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