N-methyl-D-aspartate Receptor Antagonist Desegregates Eye-Specific Stripes
The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to NMDA itself, to assess the influence of NMDA receptor/channels on the eye-specific segregation of retinal ganglion cell (...
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Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 84; no. 12; pp. 4342 - 4345 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
National Academy of Sciences of the United States of America
01.06.1987
National Acad Sciences |
Subjects | |
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Abstract | The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to NMDA itself, to assess the influence of NMDA receptor/channels on the eye-specific segregation of retinal ganglion cell (RGC) terminals that occurs whenever two retinas innervate one tectal lobe. Exposure of the tectum to the active isomer of APV produces desegregation of the RGC terminals without blocking electrical activity in the afferents or altering their terminal arbor morphology. Exposure to the inactive isomer of APV causes no perturbation of the normal stripe pattern. APV-induced desegregation is completely reversible within 2 weeks of removal of the APV. In addition, exposure of the optic tectum to NMDA results in stripes with sharper borders and fewer forks and fusions than untreated animals. These results suggest that the NMDA receptor/channel plays a role in eye-specific segregation in the three-eyed tadpole. |
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AbstractList | The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to NMDA itself, to assess the influence of NMDA receptor/channels on the eye-specific segregation of retinal ganglion cell (RGC) terminals that occurs whenever two retinas innervate one tectal lobe. Exposure of the tectum to the active isomer of APV produces desegregation of the RGC terminals without blocking electrical activity in the afferents or altering their terminal arbor morphology. Exposure to the inactive isomer of APV causes no perturbation of the normal stripe pattern. APV-induced desegregation is completely reversible within 2 weeks of removal of the APV. In addition, exposure of the optic tectum to NMDA results in stripes with sharper borders and fewer forks and fusions than untreated animals. These results suggest that the NMDA receptor/channel plays a role in eye-specific segregation in the three-eyed tadpole. The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to NMDA itself, to assess the influence of NMDA receptor/channels on the eye-specific segregation of retinal ganglion cell (RGC) terminals that occurs whenever two retinas innervate one tectal lobe. Exposure of the tectum to the active isomer of APV produces desegregation of the RGC terminals without blocking electrical activity in the afferents or altering their terminal arbor morphology. Exposure to the inactive isomer of APV causes no perturbation of the normal stripe pattern. |
Author | Cline, Hollis T. Debski, Elizabeth A. Constantine-Paton, Martha |
Author_xml | – sequence: 1 givenname: Hollis T. surname: Cline fullname: Cline, Hollis T. – sequence: 2 givenname: Elizabeth A. surname: Debski fullname: Debski, Elizabeth A. – sequence: 3 givenname: Martha surname: Constantine-Paton fullname: Constantine-Paton, Martha |
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SubjectTerms | 2-Amino-5-phosphonovalerate Afferent Pathways - anatomy & histology Afferent Pathways - drug effects Afferent Pathways - physiology Animals Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Behavioral neuroscience Biological and medical sciences Cell separation Desegregation Evoked Potentials, Visual - drug effects Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology N-Methylaspartate Neurons Optics Rana pipiens Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - physiology Stripes Superior Colliculi - drug effects Superior Colliculi - physiology Superior colliculus Synapses Tadpoles Valine - analogs & derivatives Valine - pharmacology Vertebrates: nervous system and sense organs |
Title | N-methyl-D-aspartate Receptor Antagonist Desegregates Eye-Specific Stripes |
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