Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

• Published in: Cell metabolism Vol. 32; no. 1; pp. 44 - 55.e6
• Main Authors: Bharath, Leena P., Agrawal, Madhur, McCambridge, Grace, Nicholas, Dequina A., Hasturk, Hatice, Liu, Jing, Jiang, Kai, Liu, Rui, Guo, Zhenheng, Deeney, Jude, Apovian, Caroline M., Snyder-Cappione, Jennifer, Hawk, Gregory S., Fleeman, Rebecca M., Pihl, Riley M.F., Thompson, Katherine, Belkina, Anna C., Cui, Licong, Proctor, Elizabeth A., Kern, Philip A., Nikolajczyk, Barbara S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.07.2020
• Subjects: autophagy; inflammaging; metformin; mitochondria; T cells; metformin; inflammaging; autophagy; T cells; mitochondria

Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4+ T cells from lean, normoglyce...