Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma

• Published in: iScience Vol. 4; pp. 312 - 325
• Main Authors: Chatterjee, Aniruddha, Rodger, Euan J., Ahn, Antonio, Stockwell, Peter A., Parry, Matthew, Motwani, Jyoti, Gallagher, Stuart J., Shklovskaya, Elena, Tiffen, Jessamy, Eccles, Michael R., Hersey, Peter
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.06.2018; Elsevier
• Subjects: Cancer; Genetics; Genomics; Transcriptomics; Genetics; Transcriptomics; Genomics; Cancer

Constitutive expression of the immune checkpoint, PD-L1, inhibits anti-tumor immune responses in cancer, although the factors involved in PD-L1 regulation are poorly understood. Here we show that loss of global DNA methylation, particularly in intergenic regions and repeat elements, is associated wi...