Multivariate pattern analysis links drug use severity to distributed cortical hypoactivity during emotional inhibitory control in opioid use disorder

• Published in: NeuroImage clinical Vol. 32; p. 102806
• Main Authors: Shi, Zhenhao, Langleben, Daniel D., O'Brien, Charles P., Childress, Anna Rose, Wiers, Corinde E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2021; Elsevier
• Subjects: Craving; Delayed-Action Preparations - therapeutic use; Drug use severity; Emotional inhibitory control; Emotions; Functional magnetic resonance imaging; Humans; Multivariate pattern analysis; Naltrexone - therapeutic use; Narcotic Antagonists - therapeutic use; Opioid use disorder; Opioid-Related Disorders - diagnostic imaging; Opioid-Related Disorders - drug therapy; Regular; Emotional inhibitory control; Functional magnetic resonance imaging; Multivariate pattern analysis; Opioid use disorder; Craving; Drug use severity

•Cortical hypoactivity during inhibitory control predicted greater opioid use severity.•Frontoparietal brain networks significantly contributed to the prediction of severity.•Brain marker of severity predicted subsequent on-treatment opioid craving.•Brain marker predicted on-treatment craving better...