Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

• Published in: Cell systems Vol. 6; no. 3; pp. 282 - 300.e2
• Main Authors: Berger, Ashton C., Hurlin, Peter J., Eisenman, Robert N., Felau, Ina, Zhang, Jiashan (Julia), Kim, Jaegil, Kramer, Roger, Reynolds, Sheila, Shmulevich, Ilya, Thorsson, Vesteinn, Liang, Han, Lu, Yiling, Ng, Kwok-Shing, Gao, Jianjiong, Heins, Zachary J., La, Konnor, Schultz, Nikolaus, Taylor, Barry S., Bowlby, Reanne, Lee, Darlene, Mungall, Karen, Schein, Jacqueline E., Schumacher, Steven E., Hoyle, Alan P., Perou, Amy H., Skelly, Tara, Chang, Kyle, Shinbrot, Eve, Wang, Min, Xi, Liu, Schmidt, Heather K., Curley, Erin, Gardner, Johanna, Morris, Scott, Paulauskis, Joseph, Longatto-Filho, Adhemar, Kibel, Adam, Devine, Karen, Ostrom, Quinn T., Shimmel, Kristen, Harr, Jodi, Zach, Leigh Anne, Kvecher, Leonid, Latour, Mathieu, Têtu, Bernard, McGraw, Mary, Chen, Amy, Sica, Gabriel, Van Meir, Erwin G., Calatozzolo, Chiara, Mattei, Luca, Pollo, Bianca, Houck, John, Bueno, Raphael, Girard, Nicolas, Aymerich, Marta, Stepa, Serghei, Hoon, Dave, Beuschlein, Felix, Chandan, Vishal, Moser, Catherine, O’Brien, Daniel, Thompson, R. Houston, Torbenson, Michael, Behrens, Carmen, Tsao, Anne, Jakrot, Valerie, Lee, Kenneth, Spillane, Andrew, Chan, Timothy A., Park, Joong-Won, Kebebew, Electron, Thomas, George, Facciolo, Francesco, Piché, Alain, Pennell, Nathan A., Morrison, Carl, Seder, Christopher W., Bragazzi, Maria Consiglia, Gaudio, Eugenio, Becker, Karl-Friedrich, Bell, Sue, Hilty, Joe, Grizzle, William E., Porten, Sima, Asa, Sylvia L., Sauter, Guido, Schlomm, Thorsten, Bathe, Oliver, Phillips, Joanna, Prados, Michael, Sifri, Suzanne, Forgie, Ian, Mannelli, Massimo, Herold-Mende, Christel, Landrum, Lisa, Kemp, Rafael, Rathmell, W. Kimryn, Fantacone-Campbell, J. Leigh, Mariamidze, Armaz
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.03.2018
• Subjects: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biomarkers, Tumor - genetics; Carcinogenesis - genetics; Chromatin; Computational Biology - methods; Genes, myc - genetics; Genes, myc - physiology; Genomics; Humans; MAX; MNT; MYC genomic alterations; Neoplasms - genetics; Neoplasms - physiopathology; Oncogenes; Proteomics; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - physiology; Repressor Proteins - genetics; Repressor Proteins - metabolism; Signal Transduction - genetics; TCGA; The Cancer Genome Atlas; Transcription Factors - genetics; MNT; MAX; MYC genomic alterations; TCGA; The Cancer Genome Atlas

Although the MYC oncogene has been implicated in cancer, a systematic assessment of alterations of MYC, related transcription factors, and co-regulatory proteins, forming the proximal MYC network (PMN), across human cancers is lacking. Using computational approaches, we define genomic and proteomic...