Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes

• Published in: The Journal of biological chemistry Vol. 283; no. 32; pp. 21837 - 21841
• Main Authors: Grimsrud, Paul A., Xie, Hongwei, Griffin, Timothy J., Bernlohr, David A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.08.2008; American Society for Biochemistry and Molecular Biology
• Subjects: Aldehydes - metabolism; Animals; Electrophoresis, Gel, Two-Dimensional; Humans; Mass Spectrometry; Minireviews; Oxidative Stress; Protein Carbonylation; Proteins - chemistry; Proteins - metabolism; Proteomics; Reactive Oxygen Species - metabolism

The term “oxidative stress” links the production of reactive oxygen species to a variety of metabolic outcomes, including insulin resistance, immune dysfunction, and inflammation. Antioxidant defense systems down-regulated due to disease and/or aging result in oxidatively modified DNA, carbohydrates...