Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis

• Published in: The Lancet. Psychiatry Vol. 10; no. 9; p. 693
• Main Authors: Yildiz, Ayşegül, Siafis, Spyridon, Mavridis, Dimitris, Vieta, Eduard, Leucht, Stefan
• Format: Journal Article
• Language: English
• Published: England 01.09.2023
• Subjects: Adult; Bipolar Disorder - drug therapy; Depression; Drug-Related Side Effects and Adverse Reactions; Female; Fluoxetine; Humans; Lamotrigine; Lurasidone Hydrochloride; Male; Middle Aged; Olanzapine; Quetiapine Fumarate

Bipolar depression constitutes a major public health problem due to its substantial burden of disease. Although pharmacological interventions are available, guidelines required updated evidence synthesis to improve their current recommendations. In order to inform evidence-based prescribing, we inve...